Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus
References (12)
- et al.
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
Biochem. J.
(1982) - et al.
Central serotonin receptors: effector systems, physiological roles and regulation
Psychopharmacology
(1987) - et al.
Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked 5-HT-2 and 5-HT-1c receptors
J. Pharmacol. Exp. Ther.
(1987) - et al.
Culture and characterization of epithelial cells from bovine choroid plexus
J. Neurochem.
(1981) - et al.
Subtypes of receptors for serotonin
Annu. Rev. Pharmacol. Toxicol.
(1990) Do classical hallucinogens act as 5-HT2 agonists or antagonists?
Neuropsychopharmacology
(1990)
Cited by (13)
Serotonin and serotonin receptors in hallucinogen action
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :This chapter will review the receptor interactions that contribute to the behavioral effects of hallucinogens and MDMA. The 5-HT2A receptor is a Gq/11-coupled receptor that is linked to the phosphoinositide hydrolysis signaling cascade (Barker, Burris, & Sanders-Bush, 1991; Nichols & Nichols, 2008). Members of both the indoleamine and phenylalkylamine classes of hallucinogens bind to 5-HT2A receptors with high-affinity.
Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2- aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex
2013, Brain ResearchCitation Excerpt :As in the current study, DOI-stimulated PI hydrolysis has previously been blocked by 5-HT2A antagonists in cortical tissue (Edwards et al., 1992; Pierce and Peroutka, 1988). The LSD-stimulated signal was also blocked by ketanserin in cell models, but at 10 to 20 times the LSD concentration (Barker et al., 1991; Egan et al., 1998). One study reported complete blocking of the LSD-stimulated PI hydrolysis in rat cortical slices by ketanserin, but the data were not shown (Sanders-Bush et al., 1988).
Serotonin activates Cl<sup>-</sup> channels in the apical membrane of rat choroid plexus epithelial cells
1993, European Journal of PharmacologyReceptors for 5-hydroxytryptamine
1993, New Comprehensive Biochemistry
This work was supported by ADAMHA research Grants DA 05181 and MH 34007 and NIH training grant GM 07628.
- 1
Special thanks to Marsha Breeding for her assistance with cell cultures.