Adrenergic modulation of calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric resistance vessel
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Nerve growth factor facilitates perivascular innervation in neovasculatures of mice
2016, Journal of Pharmacological SciencesCitation Excerpt :CGRP is well known to be a vasodilator neurotransmitter for non-adrenergic non-cholinergic nerves (1). When perivascular CGRPergic nerves are electrically stimulated, the neurotransmitter CGRP is released from the nerves and activates CGRP receptors on vascular smooth muscle cells, causing potent vasodilatation (1,21). In the present immunohistochemical study, microvessels in the mouse adipose tissue were innervated by perivascular CGRP-LI nerve fibers, suggesting that CGRPergic nerves acts as a vasodilator nerves in microvessels.
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