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Cited by (187)
Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor
2022, Journal of Chemical Neuroanatomy5.32 - Joint Pain
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionAntagonism of substance P and perception of breathlessness in patients with chronic obstructive pulmonary disease
2014, Respiratory Physiology and NeurobiologyCitation Excerpt :Like endogenous opioids, substance P plays a key role in nociception. In response to a noxious stimulus, substance P is released from terminals of sensory nerve fibers that transmit pain impulses from peripheral NK-1 receptors to the CNS (Stein and Lang, 2009; Duggan et al., 1988; Schaible et al., 1990). Like endogenous opioids, substance P and the NK-1 receptor are present in the respiratory system, being found in bronchial smooth muscle, blood vessels, mucous glands, immune cells, and sensory nerves (Kudlacz et al., 1993).
Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response
2011, NeuropharmacologyCitation Excerpt :Numerous studies have documented the presence of substance P in sensory afferent fibers in the dorsal root ganglia and the dorsal horn of the spinal cord (Pernow, 1983). Substance P is released from the spinal cord following various nociceptive stimuli (Duggan et al., 1987; Kantner et al., 1985; Schaible et al., 1990) and administrations of capsaicin through peripheral and intrathecal (i.t.) routes (Gamse et al., 1979; Go and Yaksh, 1987). Following release and binding to neurokinin1 (NK1) receptor, the biological action of substance P is terminated by enzymatic degradation (Lee et al., 1981; Matsas et al., 1984; Nyberg and Terenius, 1991).
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1, 2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
2010, PainCitation Excerpt :In support, in a cat acute arthritic knee joint model, nociception alone was not sufficient to stimulate SP release. Spinal SP release was only induced after severe stimuli or damaging insults [42]. CGRP [27], glutamate [26,29], and bradykinin [28,38] have been shown to sensitize nociceptors, either directly or indirectly, suggesting that TRPV1 may be sensitized in OA rats.
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Present address: Physiologisches Institut der Universität Wurzburg, F.R.G.
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Present address: Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Melbourne, Victoria Australia.