5-HT3 receptors modulate spinal nociceptive reflexes
Reference (47)
- et al.
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Neuropharmacology
(1986) - et al.
Intrathecal 5-hydroxytryptamine and electrical stimulation of the nucleus raphe magnus in rats both reduce the antinociceptive potency of intrathecally administered noradrenaline
Brain Research
(1988) - et al.
Interdependence of spinal adenosinergic, serotonergic and noradrenergic systems mediating antinociception
Neuropharmacology
(1987) - et al.
Effects of the putative 5-HT1A receptor agonist8-OH-2-(di-n-propylamino)tetraline on nociceptive sensitivity in mice
Pharmacol. Biochem. Behav.
(1986) - et al.
Identification of 5-HT3 binding sites in rat spinal cord synaptosomal membranes
Eur. J. Pharmacol.
(1988) - et al.
Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methylsergide
Brain Research
(1980) - et al.
Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine
Brain Research
(1984) - et al.
Evidence for bulbospinal serotonergic pressor pathway in the rat brain
Brain Research
(1983) Peripheral 5-hydroxytryptamine receptors and their classification
Neuropharmacology
(1984)- et al.
Separate involvement of the spinal noradrenergic and serotonergic systems in morphine analgesia: the differences in mechanical and thermal algesic tests
Brain Research
(1983)
Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: mechanical and thermal algesic tests
Brain Research
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
Brain Research
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Brain Research
[3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes
Eur. J. Pharmacol.
Morphine analgesia: blockade by raphe magnus lesions
Brain Research
The pharmacology and function of 5-HT3 receptors
Trends Neurosci.
Increase of serotonin metabolism within the dorsal horn of the spinal cord during nucleus raphe magnus stimulation, as revealed by in vivo electrochemical detection
Brain Research
Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord
Eur. J. Pharmacol.
Chronic catheterization of the spinal subarachnoid space
Physiol. Behav.
Opiate and stimulus produced analgesia: functional anatomy of a medullospinal pathway
Peripheral and spinal mechanisms of nociception
Physiol. Rev.
Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum. Evidence for two distinct release mechanisms
Nauyn-Schmiedeberg's Arch. Pharmacol.
Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptor
Br. J. Pharmacol.
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Serotonin—pain modulation
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :For example, intrathecal administration of a 5-HT3R agonist (2-methyl-5-HT) inhibited nociceptive reflexes in the tail flick and hot plate tests in normal animals, and this effect was blocked with a 5-HT3R antagonist (ICS205-930) or antisense oligodeoxynucleotides directed at 5-HT3R, but also by a GABA receptor antagonist (Alhaider, Lei, & Wilcox, 1991; Glaum, Proudfit, & Anderson, 1990; Paul, Yao, Zhu, Minor, & Garcia, 2001). Conversely, a 5-HT3R antagonist (ICS205-930) at a relatively high dose was pronociceptive in the tail flick and hot plate tests (Glaum, Proudfit, & Anderson, 1988), though 5-HT3R antagonists (ICS205-930, MDL72222 and Y25130) had no effect on thermal or mechanical sensitivities in other studies (Ali, Wu, Kozlov, & Barasi, 1996; Glaum et al., 1990; Guo et al., 2014). Dorsal horn neuronal responses were also unaffected by an intrathecal 5-HT3R antagonist (ondansetron) (Green, Scarth, & Dickenson, 2000).
The inhibitory effect of granisetron on ventrolateral medulla neuron responses to colorectal distension in rats
2015, European Journal of PharmacologyCitation Excerpt :However, at the same time it has been demonstrated that serotonin via an action at spinal 5-HT3 receptor sites may evoke release of gamma-aminobutyric acid (GABA) in the spinal inhibitory interneurons, which may in turn inhibit a nociceptive transmission at the postsynaptic site on terminals of the primary afferent fibers (Alhaider et al., 1991). Moreover, intrathecal administration of 5-HT3 receptor-specific agonist 2-methyl-serotonin (2-Me-5-HT) has shown antinociceptive responses in behavioral nociceptive tests such as the formalin test (Giordano, 1991; Sasaki et al., 2001), tail flick and hot plate tests (Glaum et al., 1990). 5-HT3 receptor-mediated facilitation of the GABA-ergic inhibition of synaptic transmission in the spinal cord was also demonstrated in-vitro (Fukushima et al., 2009).
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: The role of 5-HT <inf>3</inf> receptors
2012, European Journal of PharmacologyFurther analyses of mechanisms underlying the antinociceptive effect of the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene in mice
2011, European Journal of Pharmacology
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Present address: Department of Pharmacological and Physiological Sciences, University of Chicago, 947 E. 58th Street, Chicago, IL 60637, U.S.A.