The role of spinal cord 5-HT1A and 5-HT1B receptors in the modulation of a spinal nociceptive reflex
Reference (36)
- et al.
Complete blockade and attenuation of 5-hydroxytryptamine induced analgesia following NA depletion in rats and mice
Acta Pharmacol. Toxicol.
(1986) - et al.
(+)—8-OH-DPAT and 5-MeODMT induced analgesia is antagonized by noradrenaline depletion
Physiol. Behav.
(1987) - et al.
Denervation supersensitivity to 5-hydroxytryptophan in rats following spinal transection and 5,7-dihydroxytryptamine injection
Neuropharmacology
(1981) Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats
Pain
(1982)- et al.
Alterations in serotonin binding sites after 5,7-dihydroxytryptamine treatment in the rat spinal cord
Neurosci. Lett.
(1989) - et al.
The role of tail skin temperature in the facilitation of the tail-flick reflex after spinal transection or interference with descending serotonergic neurotransmission
Acta Physiol. Scand.
(1989) - et al.
Effects of serotonin receptor antagonists and agonists on the tail-flick response in mice involve altered tail-skin temperature
Neuropharmacology
(1988) - et al.
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: Differential effects on the sensitiviy to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests
Brain Research
(1988) - et al.
Effects of the putative 5-HT1A receptor agonist8-OH-2-(di-n-propylamino)tetralin on nociceptive sensitivity in mice
Pharmacol. Biochem. Behav.
(1986) - et al.
Identification of presynaptic serotonin autoreceptors using a new ligand:3H-PAT
Nature (Lond.)
(1983)
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors
Neuropharmacology
Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6,-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration
J. Pharmacol. Exp. Ther.
Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain
Trends Pharmacol. Sci.
Intrathecal morphine in mice: a new technique
Eur. J. Pharmacol.
Serotonin and pain
The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space
J. Physiol. (Lond.)
Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity
J. Pharmacol. Exp. Ther.
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site
Eur. J. Pharmacol.
Cited by (68)
Serotonin—pain modulation
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :The Gi/o coupled 5-HT1A-FR subtypes are present in the dorsal horn, largely postsynaptically, and activation has largely antinociceptive effects in various pain models (Bardin, 2011; Colpaert, 2006; Cortes-Altamirano et al., 2018). Spinal (intrathecal) application of agonists for 5-HT1AR or 5-HT1BR had inhibitory (Eide, Joly, & Hole, 1990; Jeong, Mitchell, & Vaughan, 2012; Xu, Qiu, & Han, 1994) and facilitatory (Bardin & Colpaert, 2004) effects on nociceptive responses to heat or mechanical stimuli (Ali, Wu, Kozlov, & Barasi, 1994; Bardin & Colpaert, 2004). Agonists for 5-HT1DR or 5-HT1FR had no behavioral effect (Jeong et al., 2012).
Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model
2018, Pharmacological ReportsCitation Excerpt :5-HT1 family receptors are present in the whole spinal cord and in the grey matter in all the areas examined, and it is the major class of 5-HT receptor found in the dorsal horn [24,25]. Eide et al. [26] examined whether the administration of 5-HT1A and 5-HT1B receptor agonists in mice could alter the tail-flick reflex and whether the effects on reflex latency involve changes in tail-skin temperature; the authors found that in the mouse, both 5-HT1A and 5-HT1B receptor agonists inhibit the nociceptive tail-flick reflex when injected into the spinal subarachnoid space, and that the effect does not depend on changes in tail-skin temperature. We think that perhaps 5-HT1 receptors participate in the antinociceptive modulation of LEV at high doses.
Spinal 5-HT<inf>5A</inf> receptors mediate 5-HT-induced antinociception in several pain models in rats
2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :In the case of the formalin test, it seems that serotonergic descending inhibition is important to develop primary hyperalgesia while descending facilitation participates in secondary hyperalgesia (Vanegas and Schaible, 2004). Stimulation of spinal 5-HT1 (Eide et al., 1990; Nadeson and Goodchild, 2002; Jeong et al., 2012) receptors produces antinociceptive effects whereas activation of spinal 5-HT2 (Rahman et al., 2011; Cervantes-Durán et al., 2012), 5-HT3 (Alhaider et al., 1991; Oyama et al., 1996; Dogrul et al., 2009; Asante and Dickenson, 2010), 5-HT4 (Liu et al., 2007), 5-HT6 (Castañeda-Corral et al., 2009) and 5-HT7 (Rocha-González et al., 2005; Brenchat et al., 2009; Amaya-Castellanos et al., 2011) receptors instead elicits pronociceptive effects. Nevertheless, to the best of our knowledge, no study has investigated the role of spinal 5-HT5 receptors in the modulation of nociception in rats.
Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury
2010, NeuroscienceCitation Excerpt :On the one hand, the presence of subtypes A (Wu et al., 2001; Zhang et al., 2002; Wang et al., 2003) and B (Wu et al., 2001) in primary afferent neurones may be expected to inhibit neurotransmitter release and thus to reduce nociception, whereas on the other, 5-HT1A receptor-expression in spinal GABAergic and enkephalinergic neurones (Wu et al., 2001; Wang et al., 2003) is rather consistent with disinhibition of nociception. Activation of the spinal 5-HT1B receptor can potentiate (Zhang et al., 2001a) or inhibit (Liu et al., 2007) evoked responses in wide dynamic range neurones, although behavioural evaluations appear to favour an antinociceptive role (Eide et al., 1990; Jeong et al., 2004). We show that selective agonists for receptor subtypes A or B depress field potentials evoked by electrical activation of C fibres (Fig. 1).
Inhibition of opioid release in the rat spinal cord by serotonin 5-HT<inf>1A</inf> receptors
2007, Brain ResearchCitation Excerpt :By inhibiting spinal opioid release, 5-HT1A receptors would decrease opioid-mediated analgesia, resulting in an overall pro-algesic effect. Previous studies on the effect of 5-HT1A receptors on pain responses have provided conflicting results, including both analgesic (Danzebrink and Gebhart, 1991; Eide et al., 1990; el-Yassir et al., 1988; el-Yassir and Fleetwood-Walker, 1990; Gjerstad et al., 1996; Oyama et al., 1996; Xu et al., 1994) and hyperalgesic effects (Alhaider and Wilcox, 1993; Ali et al., 1994; Crisp et al., 1991; Murphy and Zemlan, 1990; Solomon and Gebhart, 1988; Zemlan et al., 1988). Therefore, it is likely that 5-HT1A receptors produce multiple actions in the spinal cord with opposite results on pain modulation.