Research reportSubstance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2
References (18)
- et al.
Neurochemical studies in the hypoxic brain: substance P, Met-enkephalin, GABA and angiotensin converting enzyme
Life Sci.
(1981) - et al.
Substance P: a carotid body peptide
Neurosci. Lett.
(1980) - et al.
Effects of methionine-enkephalin and substance P on the chemosensory discharge of the cat carotid body
Brain Research
(1985) - et al.
Substance P-like immunoreactivity in rat and cat carotid bodies: light and electron microscopic studies
Histol. Histopathol.
(1986) - et al.
Physiological chemoreceptor stimulation decreases enkephalin and substance P in the carotid body
Peptides
(1986) - et al.
Thyroid hormone status regulates preprotachykinin gene expression in male rats
Endocrinology
(1987) - et al.
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A
- et al.
Peptides in the carotid body (glomus caroticum): VIP-enkephalin and substance P-like immunoreactivity
Acta Physiol. Scand.
(1979) Effects of substance P on carotid chemoreceptor activity in the cat
J. Physiol. (Lond.)
(1980)
Cited by (65)
Serotonin and substance P: Synergy or competition in the control of breathing
2020, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :Close carotid body injection of substance P stimulates sensory discharges of carotid sinus nerve in cats and rats (Mc Queen, 1980; Prabhakar et al., 1984; Cragg et al., 1994). Glomus cells and nerve fibers innervating the chemoreceptor tissue show SP-like immunoreactivity (Prabhakar et al., 1989) and SP binding sites were revealed in cat's carotid body (Dashwood et al., 1990). SP is coupled to hypoxic response of the cat carotid body.
Neuropeptides and breathing in health and disease
2018, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Substance P has been found in human sensory C-fibers innervating glomus cells [94] and in rabbit glomus cells and nerve fibers, where its release during hypoxia from the carotid body was observed [95]. Both SP and NKA have been confirmed to occur in the glomus cells of the cat carotid body, where they increased chemoreceptor discharges following an exogenous application [96]. Tachykinins are present in sensory nerve fibers innervating mammalian airways.
Chapter 1 Trophic Factors in the Carotid Body
2008, International Review of Cell and Molecular BiologyCitation Excerpt :Substance P (Chen et al., 1986; Cuello and McQueen, 1980; Hanson et al., 1986; Heym and Kummer, 1989; Prabhakar et al., 1989; Smith et al., 1990; Wharton et al., 1980) and neurokinin A (Prabhakar et al., 1989) immunoreactivities have been found in type I cells and nerve fibers of the mammalian carotid body. In the cat carotid body, they increased the chemosensory response to hypoxia, and substance P has been found to bind to NK‐1 receptors (Prabhakar et al., 1989). Some authors have considered the changes in tachykinin content following acute or chronic hypoxia.
Oxygen sensing in the body
2006, Progress in Biophysics and Molecular BiologyNeurotransmitters in carotid body development
2005, Respiratory Physiology and NeurobiologyTachykinins in the control of breathing by hypoxia: Pre- and post-genomic era
2003, Respiratory Physiology and Neurobiology