Substance P, neurotensin and enkephalin injections into the ventral tegmental area: comparative study on dopamine turnover in several forebrain structures
Reference (36)
Central dopamine-peptide interactions: electrophysiological studies
Neuropharmacology
(1987)- et al.
Ventral tegmental area infusion of substance P, neurotensin and enkephalin: differential effects on feeding behavior
Neuroscience
(1986) - et al.
Substance K and substance P differentially modulate mesolimbic and mesocortical systems
Peptides
(1985) - et al.
Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area
Brain Research
(1986) - et al.
Behavioral effects of neurotensin in the open-field: structure-activity studies
Brain Research
(1986) - et al.
Behavioral effects of tachykinins and related peptides
Brain Research
(1986) - et al.
A rapid method for the regional dissection of the rat brain
Pharmacol. Biochem. Behav.
(1980) - et al.
Differential effects of inescapable footshocks on dopamine turn-over in cortical and limbic areas of the rat
Life Sci.
(1982) - et al.
The behavioral effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus
Brain Research
(1981) - et al.
Increase in the spontaneous motor activity following infusion of neurotensin into the ventral tegmental area
Brain Research
(1981)
Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain
J. Neurosci. Meth.
Functional studies of the central catecholamines
Int. Rev. Neurobiol.
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Brain Res. Bull.
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines
J. Pharmacol. Exp. Ther.
Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones
Nature (Lond.)
Dopamine containing systems in the CNS
Stimulant effects of enkephalin microinjection into the dopaminergic A10 area
Nature (Lond.)
Cited by (86)
Regulation of the mesolimbic dopamine circuit by feeding peptides
2015, NeuroscienceCitation Excerpt :Neurotensin-expressing neurons in the VTA project to the NAc (Kalivas and Miller, 1984). In anesthetized rats, neurotensin injected into the VTA increases dopaminergic cell firing and increases dopamine turnover in the posterior NAc (Pinnock, 1985; Cador et al., 1989; Kalivas and Duffy, 1990; Laitinen et al., 1990; Sotty et al., 1998). Activation of NT1 receptors on cultured VTA dopamine neurons increases intracellular calcium via a phospholipase C (PLC)-mediated mechanism leading to an increase in firing rate (St-Gelais et al., 2004).
Involvement of orexin-1 receptors in the ventral tegmental area and the nucleus accumbens in antinociception induced by lateral hypothalamus stimulation in rats
2013, Pharmacology Biochemistry and BehaviorBrain kinin B<inf>1</inf> receptor contributes to the onset of stereotypic nocifensive behavior in rat
2013, Behavioural Brain ResearchCocaine sensitization does not alter SP effects on locomotion or excitatory synaptic transmission in the NAc of rats
2012, NeuropharmacologyCitation Excerpt :Identifying endogenous substances with such an action will improve our understanding of the development of addiction and may lead to new targets or therapeutic options for substance abuse treatment and related psychiatric disorders. In this regard, SP has been reported to increase extracellular dopamine concentration in the NAc (Boix et al., 1992a,b; Cador et al., 1989; Placenza et al., 2004) and also shown to utilize dopamine as an intermediate to depress EPSCs in the NAc (Kombian et al., 2003). Furthermore, this effect of SP was reported to occlude the actions of cocaine (Kombian et al., 2009).
Neuronal pathways linking substance P to drug addiction and stress
2010, Brain ResearchCitation Excerpt :Moreover, SP has effects directly within the VTA on dopamine neuronal activity. Injection of SP into the VTA increases cell-firing rates of neurons (Korotkova et al., 2006) and dopamine release in forebrain areas including the prefrontal cortex and nucleus accumbens (Cador et al., 1989; Elliott and Iversen, 1986). Reward and motivation to seek that reward, also called incentive salience, are two fundamental components of drug addiction.
Neurobiology of addiction. An integrative review
2008, Biochemical PharmacologyCitation Excerpt :Injection of SP directly into the VTA has been found to increase the levels of DA and/or its metabolites in the PFC and the NAc, suggesting that SP stimulates the release of DA from mesocortical and mesolimbic DA neurons [760–762]. SP has been shown to preferentially activate mesocortical DA neurons in a manner similar to acute stressors such as mild footshock or restraint [763]. Furthermore, evidence suggests that the increased turnover of DA in the PFC and the NAc in response to stress may be mediated by SP.