Heterogenous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes
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Cited by (98)
Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain
2016, Neuroscience LettersCitation Excerpt :The present study revealed that the 5-HT1A receptor agonist 8-OH-DPAT diminished chronic neuropathic pain related depression-like behaviour mainly by increasing swimming time and attenuated mechanical hypersensitivity of CCI animals significantly, which is in accordance with previous evidence that 8-OH-DPAT can alleviate neuropathic pain [30,31]. The analgesic effect of 8-OH-DPAT may be due to activation of postsynaptic 5-HT1A receptors on dorsal horn neurons [32–36], which mediate the inhibitory effect of the bulbospinal 5-HT system on nociceptive neurons in spinal cord dorsal horn [37]. Moreover, it could also be mediated by 5-HT1A receptors in supraspinal structures [38].
The TRPM8 channel forms a complex with the 5-HT<inf>1B</inf> receptor and phospholipase D that amplifies its reversal of pain hypersensitivity
2014, NeuropharmacologyCitation Excerpt :A variety of 5-HT receptor subtypes is expressed in dorsal root ganglia (DRG) (Chen et al., 1998; Nicholson et al., 2003; Pierce et al., 1997). One candidate with potentially appropriate characteristics is the 5-HT1B receptor (5-HT1BR), which is reported to exert an antinociceptive influence (Alhaider and Wilcox, 1993; el-Yassir et al., 1988; Granados-Soto et al., 2010; Kayser et al., 2007). Furthermore, the 5-HT1BR is associated with TrkA-positive Aδ-afferents in trigeminal ganglia (Wotherspoon and Priestley, 2000), (which could in part correspond to TRPM8-containing afferents) and is more widely expressed in DRG (Classey et al., 2010), where TRPM8 expression is increased in both Aδ and C-type afferents by neuropathic pain (Proudfoot et al., 2006).
Pronociceptive effect of 5-HT<inf>1A</inf> receptor agonist on visceral pain involves spinal N-methyl-d-aspartate (NMDA) receptor
2012, NeuroscienceCitation Excerpt :The receptor exhibits a rapid increase in the expression under pathological conditions including peripheral inflammation and spinal cord injury (Zhang et al., 2002; Otoshi et al., 2009). Some studies indicate that the activation of 5-HT1A receptors in the spinal cord and midbrain results in somatic antinociception (Gillet et al., 1985; Eide et al., 1988; El-Yassir et al., 1988; Giordano, 1989; El-Yassir and Fleetwood-Walker, 1990; Eide and Hole, 1991, 1993; Giordano and Rogers, 1992; Xu et al., 1994; Gjerstad et al., 1996; Oyama et al., 1996; Galeotti et al., 1997; Xiao et al., 2005; Wei and Pertovaara, 2006), whereas other studies report pronociceptive effect (Solomon and Gebhart, 1988; Zemlan et al., 1988; Crisp et al., 1991a,b; Alhaider and Wilcox, 1993; Ali et al., 1994; Zhang et al., 2001). Similarly, in the rodent model of visceral pain while one study indicates that the partial 5-HT1A receptor agonist buspirone produces analgesia to noxious colon distension (Sivarao et al., 2004), a recent report indicates that 5-HT1A antagonists (WAY-100635 and AZD7371) produce visceral analgesia in the same species (Lindström et al., 2009).
Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation
2008, Pharmacological ResearchCitation Excerpt :Serotonin has a complex role in pain regulation, since it has not only produced antinociceptive but also pronociceptive actions; this complexity may, at least partly, be explained by the different roles that various subtypes of serotoninergic receptors have (for review see ref. [28]). Among the many subtypes of serotonin receptors, the 5-HT1A (e.g., [29–38]), 5-HT2C [39–42], and 5-HT3 [30,34,40,43–46] receptor appear to play a significant role in serotoninergic pain regulation at the spinal cord level. All these three 5-HT receptor subtypes are expressed in the spinal dorsal horn [28].
Inhibition of opioid release in the rat spinal cord by serotonin 5-HT<inf>1A</inf> receptors
2007, Brain ResearchCitation Excerpt :By inhibiting spinal opioid release, 5-HT1A receptors would decrease opioid-mediated analgesia, resulting in an overall pro-algesic effect. Previous studies on the effect of 5-HT1A receptors on pain responses have provided conflicting results, including both analgesic (Danzebrink and Gebhart, 1991; Eide et al., 1990; el-Yassir et al., 1988; el-Yassir and Fleetwood-Walker, 1990; Gjerstad et al., 1996; Oyama et al., 1996; Xu et al., 1994) and hyperalgesic effects (Alhaider and Wilcox, 1993; Ali et al., 1994; Crisp et al., 1991; Murphy and Zemlan, 1990; Solomon and Gebhart, 1988; Zemlan et al., 1988). Therefore, it is likely that 5-HT1A receptors produce multiple actions in the spinal cord with opposite results on pain modulation.
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Present address: MRC Brain Metabolism Unit, 1 George Square, Edinburgh EH9 9JZ, U.K.