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2019, Biochemical PharmacologyCitation Excerpt :Only the shortest construct, GluN2C-855KStop resulted in UBP684 having NAM activity at GluN2C; UBP684 activity in the longer constructs was similar to WT (Fig. 1E). The neurosteroid PS, an endogenous modulator of NMDARs, potentiates GluN2A- and GluN2B- containing receptors and inhibits GluN2C- and GluN2D-containing NMDARs [27–29]. As found for UBP684, deletion of the GluN2 CTD significantly altered PS PAM activity, but with qualitatively-distinct effects.
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Present address: Department of Pharmacology, Box 3813, Duke University Medical Center, Durham, NC 27710, U.S.A.
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