Stress-induced opioid analgesia and activity in deer mice: sex and population differences

doi:10.1016/0006-8993(87)90482-3

Brain Research

Volume 425, Issue 1, 3 November 1987, Pages 49-56

https://doi.org/10.1016/0006-8993(87)90482-3 Get rights and content

Abstract

We compared restraint stress-induced opioid, analgesic and locomotory responses of 4 different populations of male and female deer mice,Peromyscus maniculatus artemisiae andP.m. nebrascensis from mainlands, andP.m. angustus andP.m. triangularis from small islands. All of the deer mice displayed immobilization-induced analgesia which was blocked by the prototypical μ-opiate antagonist, naloxone (1.0 mg/kg). In all of the populations males displayed significantly greater levels of analgesia than females. In addition, the levels of opioid-induced analgesia were significantly greater in the insular than in the mainland male and female deer mice. Restraint also induced significant increases in the locomotor activity of the mainland deer mice, while significantly decreasing the activity of the insular animals. Males displayed significantly greater stress-induced changes in locomotor activity than did females. The stress-induced increases in activity were blocked by the δ-opiate antagonist, ICI 154, 129 (10 mg/kg), while the decreases in activity were inhibited by naloxone. These results demonstrate that there are marked sex and population differences in the stress-induced, opioid-mediated responses of deer mice. These ‘pharmaco-ecological’ findings also suggest that the island-mainland population differences in behavioral responses and ecological characteristics may, in part, be related to differences in the activity of μ-, δ- and possibly other opioid systems.

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Stress-induced opioid analgesia and activity in deer mice: sex and population differences

Abstract

Neuropharmacology

Eur. J. Pharmacol.

Life Sci.

Biochem. Biophys. Res. Commun.

Comp. Biochem. Physiol.

Life Sci.

Brain Research

Brain Research

Brain Research

Life Sci.

Brain Research

Brain Research

Brain Research

Brain Research

Biochem. Pharmacol.

Life Sci.

Physiol. Behav.

Pharmacol. Biochem. Behav.

Brain Research

Brain Research

Endogenous opioids: biology and function

Annu. Rev. Neurosci.

Stress-induced analgesia: adaptive pain suppression

Physiol. Rev.

Hormonal determinants of sex differences in avoidance behavior and reactivity to electric shock in the rat

J. Comp. Physiol. Psychol.

Neuropharmacological and neuroendocrine substrates of stress-induced analgesia

Ann. N.Y. Acad. Sci.

A sex difference in endogenous opioid regulation of the posterior pituitary response to stress in the rat

J. Endocrinol.

Biochemical and physiological correlates of deer mouse α-chain hemoglobin polymorphisms

Possible physiological role of adrenal and gonadal steroids in morphine analgesia

Eur. J. Pharmacol.

Genetic selection for reproductive photoresponsiveness in deer mice

Nature (London)