Elsevier

Brain Research

Volume 362, Issue 1, 1 January 1986, Pages 175-179
Brain Research

Two brain cholecystokinin receptors: implications for behavioral actions

https://doi.org/10.1016/0006-8993(86)91413-7Get rights and content

Abstract

The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.

References (27)

  • CarpenterD.O. et al.

    Behavioral and electrophysiological studies of peptide induced emisis in dogs

  • Crawley, J.N., Hommer, D.W. and Skirboll, L.P., Topographical analysis of nucleus acumbens sites at which...
  • Crawley, J.N., Stivers, J.A., Hommer, D., Skirboll, J. and Paul, S.M., Antagonists of central and peripheral behavioral...
  • Cited by (0)

    This work was supported by NIH Grant AM19302 and by the Wellcome Trust, London, U.K.

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