Research reportRegulatory mechanisms for subtance P in the dorsal horn during a nociceptive stimulus: Axoplasmic transport vs electrical activity
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Cited by (40)
Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models
2013, NeuropeptidesCitation Excerpt :This finding is in agreement with studies that employed the formalin test in the rats’ paw, which have shown that pharmacological blockade of NK1 receptors reduced the first or both phases of nociception evoked by formalin (Birch et al., 1992; Traub, 1996). Furthermore, there are several evidences that injection of formalin in the paw leads to an increase of SP levels in the dorsal horn, probably, as the result of an increased biosynthesis, transport and release of this peptide in primary afferents and spinal neurons in response to long-lasting inflow of noxious messages (Kantner et al., 1986; Zhang et al., 1994). Altogether, these results reinforce the role of SP in persistent pain by acting at both, the peripheral level (present study), as well as at the central level, where most of the studies demonstrated increased expression of SP after formalin injection.
Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury
2010, PainCitation Excerpt :The gel was then cut into 5 mm long and 2 mm wide strips. The strips were placed on the median nerve in a “sandwich” dressing [30]. Group 4 was anesthetized and the right median nerve was exposed.
Spinal subarachnoid adrenal medullary transplants reduce hind paw swelling and peripheral nerve transport following formalin injection in rats
2008, Brain ResearchCitation Excerpt :In none of the treatment groups was SP IR noted distally to the ligation, thus confirming anterograde-only transport of SP.) However, formalin injection significantly increased SP IR in sham- and control-transplanted rats. A previous study demonstrated that retarding microtubule function with colchicine treatment of the central terminal significantly suppressed formalin-induced accumulation of SP IR in the dorsal horn (Kantner et al., 1986). Thus, the current data demonstrate that formalin increases axoplasmic transport of SP to the periphery.
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Present address: Department of Physical Therapy, Medical College of Ohio, C.S. 10008, 3000 Arlington Avenue, Toledo, OH 43699, U.S.A.