Elsevier

Brain Research

Volume 363, Issue 1, 15 January 1986, Pages 145-147
Brain Research

Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

https://doi.org/10.1016/0006-8993(86)90667-0Get rights and content

Abstract

Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5, MePhe8, Sar9]-SP5–11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocotical and mesolimbic DA neurones.

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Present adress: Department of Psychiatry, Yale University School of Medicine, and the Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, U.S.A.

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