An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
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2018, Physiology and BehaviorCitation Excerpt :Indeed, NPY ablation results in a similar compensatory upregulation of hypothalamic and hindbrain NPY expression and a resultant increase in food deprivation-induced food intake in other rodents [71,72]. Hindbrain NPY-producing neurons and Arc AgRP neurons project to the same hypothalamic nuclei (i.e. PVH) and may therefore contribute to, at the very least, the food deprivation-induced increases in food intake through similar mechanisms [73,74]. Although these results, together with mice and rat studies, clearly demonstrate an important role for the Arc in regulating ingestive behaviors, neuronal ablation prohibits interrogation of discrete neuronal populations.
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Visiting researcher from the Medical School of China, Shenyang, China.
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