Kainic acid-induced seizures: Dose-relationship of behavioural neurochemical and histopathological changes
Reference (32)
- et al.
Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy
Neuroscience
(1981) - et al.
Injection of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy
Neuroscience
(1980) - et al.
The nature and time course of neuronal alterations resulting from oligemia and hypoglycemia in the brain ofMacaca mulatta
Brain Research
(1971) - et al.
Kainic acid neurotoxicity; effect of systemic injection on neurotransmitter markers in different brain regions
Brain Research
(1981) - et al.
Systemic injection of kainic acid: effect on neurotranmitter markers in pyriform cortex, amygdaloid complex and hippocampus and protection by cortical lesioning and anticonvulsants
Neuroscience
(1982) - et al.
Kainic acid-induced limbic seizures: metabolic behavioural, electroencephalographic and neuropathological correlates
Brain Research
(1981) - et al.
‘Epileptic’ brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology
Brain Res. Bull.
(1983) - et al.
Acute dendrotoxic changes in the hippocampus of kainate treated rats
Brain Research
(1979) - et al.
Kainic acid: a powerful neurotoxic analogue of glutamate
Brain Research
(1974) - et al.
Some properties ofl-glutamic decar☐ilase in mouse brain
Biochem. Pharmacol.
(1963)
Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study
Neuroscience
(1980)
On the relationship between kainic acid-induced epileptiform activity and hippocampal neuronal damage
Neuropharmacology
(1981)
Kainic acid-induced changes of serotonin and dopamine metabolism in the striatum and substantia nigra of the rat
Europ. J. Pharmacol.
(1981)
Kainic acid-induced seizures: neurochemical and histopathological changes
Neuroscience
(1983)
The behavioural effects of systemically administered kainic acid: a pharmacological analysis
Life Sci.
(1981)
Kainic acid neurotoxicity and seizures
Neuropharmacology
(1981)
Cited by (187)
Brain pathology in focal status epilepticus: evidence from experimental models
2021, Neuroscience and Biobehavioral ReviewsResting state functional network disruptions in a kainic acid model of temporal lobe epilepsy
2017, NeuroImage: ClinicalEffects of NMDA and non-NMDA ionotropic glutamate receptors in the medial preoptic area on body temperature in awake rats
2016, Journal of Thermal BiologyCitation Excerpt :Similar dose and recording schedule was followed for AMPA and its antagonist GAMS. Equimolar dose of kainic acid microinjection as that of the other two excitatory amino acids in the behaving rats caused seizure-like activity, circling behaviour and ultimately cell body lesion (Sperk et al., 1985). So we used a lower dose for kainic acid (0.06 nM) (Silveira and Graeff, 1992) in the other groups (n=5).
The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice
2015, Journal of the Neurological Sciences
We would like to dedicate this paper to Prof. Dr. H. Klupp on the occasion of his 65th birthday.
Copyright © 1985 Published by Elsevier B.V.