Insulin inhibits pyramidal neurons in hippocampal slices
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2019, NeuroscienceCitation Excerpt :Although there is evidence demonstrating modulation of insulin on various ion channels at the single-cell level and modification of synaptic plasticity at neural circuitry activity, these data are insufficient to illuminate insulin's modulation on brain activity at a higher level. The mechanisms by which insulin inhibits neural activity at single cell and circuit levels (Palovcik et al., 1984; Jin et al., 2011), while promoting integral brain activity and enhancing learning and memory (Kullmann et al., 2017) remain poorly understood. To address this seeming contradiction, we set out to test the impact of insulin on basal fEPSP and synaptic plasticity in hippocampal slices using a variety of experimental paradigms and interventions.
This research was supported by NIH Grant HD 16722 to M.K.R. and M.S.K., NSF Grant BNS 8025969 and NIH Grant HL 27334 to M.I.P.R.A.P. is a Post Doctoral Fellow.
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The authors wish to thank Ms. Sheri Jones for typing the manuscript.