Elsevier

Brain Research

Volume 290, Issue 2, 9 January 1984, Pages 348-352
Brain Research

Two types of acetylcholine receptors on the soma of primary afferent neurons

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Abstract

Acetylcholine (ACh) caused two types of depolarizations of the soma membrane of bullfrog primary afferent neurons (dorsal root ganglion cells); the one, a rapid transient depolarization, was nicotinic and other, a long-lasting one, as muscarinic in nature, respectively. The rapid transient depolarization was due to a simultaneous increase in sodium and potassium conductance, whereas the slow one was caused by a decrease in membrane potassium conductance. These results indicate that the soma of bullfrog primary afferent neuron is endowed with nicotinic and muscarinic receptors.

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    Dorsal root ganglia (DRG) neurons of different animal species express both nicotinic (nAChRs) [11,21] and muscarinic receptors (mAChRs) [21,28,34,35].

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This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

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We wish to thank Dr. R. A. North for helpful criticisms on the manuscript.

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