Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents
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The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord
2018, Progress in NeurobiologyCitation Excerpt :The first localization of SGR opioid receptors was carried out in rat using autoradiography with [3H]diprenorphine, a potent opiate antagonist (Pert et al., 1976). Then, it was demonstrated that opioid receptors played a role in morphine analgesia (Johnson and Duggan, 1981). Other autoradiography studies in monkey (Wamsley et al., 1982), humans (Czlonkowski et al., 1983) and rat (Waksman et al., 1986) confirmed the abundance of opioid receptors in SGR.
Differential activation of trigeminal C or Aδ nociceptors by infrared diode laser in rats: Behavioral evidence
2005, Brain ResearchCitation Excerpt :Low doses of morphine have been shown to preferentially attenuate nociceptive responses elicited by C-fiber stimulation: Carstens et al. [8] found that lower doses of systemic morphine produced presynaptic inhibition of C nociceptor input than of Aδ and Aβ afferents. LeBars et al. [31] and Johnson and Duggan [25] showed that systemic morphine preferentially attenuates responses of dorsal horn neurons to C-fiber input. Jurna and Heinz [26] described a preferential effect of systemic morphine on responses of spinothalamic and spinoreticular cells to input from unmyelinated nociceptors.
Cellular and molecular mechanisms of opioid action
2000, Progress in Brain Research