Elsevier

Brain Research

Volume 207, Issue 1, 23 February 1981, Pages 223-228
Brain Research

Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents

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Abstract

In barbiturate anaesthetized cats, dorsal horn neurones were excited by electrical stimulation of the common tibial nerve. The numbers of action potentials evoked by excitation of C fibres were depressed by analgesic doses of morphine (1–4 mg/kg i.v.). Naloxone, administered electrophoretically in the substantia gelatinosa, fully reversed the inhibitory action of morphine. The results suggest that opiate receptors in the substantia gelatinosa play a role in morphine analgesia.

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