Recurrent inhibition in the rat neostriatum

doi:10.1016/0006-8993(80)91217-2

Brain Research

Volume 194, Issue 2, 4 August 1980, Pages 359-369

https://doi.org/10.1016/0006-8993(80)91217-2 Get rights and content

Summary

During intracellular recording, in the neostriatum of rats anesthetized with urethane, the triggering of an action potential in the recorded neuron by a depolarizing pulse of current resulted in inhibition in that same neuron. This inhibition was evident through its ability to reduce the amplitude of EPSPs evoked from stimulation of substantia nigra. The shunting of SN EPSPs was shown not to be due to action potential currents. The inhibition is antagonized by the GABA blocking agent bicuculline. Intracellular labeling of recorded neurons revealed them as medium spiny neurons. It is concluded that the extensive axon collaterals of spiny projection neurons mediate recurrent inhibition, a portion of which involves autaptic synapses of a neuron back onto itself.

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We study the effects of an autapse, which is mathematically described as a self-feedback loop, on the propagation of weak, localized pacemaker activity across a Newman–Watts small-world network consisting of stochastic Hodgkin–Huxley neurons. We consider that only the pacemaker neuron, which is stimulated by a subthreshold periodic signal, has an electrical autapse that is characterized by a coupling strength and a delay time. We focus on the impact of the coupling strength, the network structure, the properties of the weak periodic stimulus, and the properties of the autapse on the transmission of localized pacemaker activity. Obtained results indicate the existence of optimal channel noise intensity for the propagation of the localized rhythm. Under optimal conditions, the autapse can significantly improve the propagation of pacemaker activity, but only for a specific range of the autaptic coupling strength. Moreover, the autaptic delay time has to be equal to the intrinsic oscillation period of the Hodgkin–Huxley neuron or its integer multiples. We analyze the inter-spike interval histogram and show that the autapse enhances or suppresses the propagation of the localized rhythm by increasing or decreasing the phase locking between the spiking of the pacemaker neuron and the weak periodic signal. In particular, when the autaptic delay time is equal to the intrinsic period of oscillations an optimal phase locking takes place, resulting in a dominant time scale of the spiking activity. We also investigate the effects of the network structure and the coupling strength on the propagation of pacemaker activity. We find that there exist an optimal coupling strength and an optimal network structure that together warrant an optimal propagation of the localized rhythm.
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We study the effect of the delayed feedback loop on the weak periodic signal detection performance of a stochastic Hodgkin–Huxley neuron. We consider an electrical autapse characterized by its coupling strength and delay time. The stochastic Hodgkin–Huxley neuron exhibits subthreshold oscillations, and thus has an intrinsic time scale with the subthreshold oscillations. Therefore, we investigate the interplay of the subthreshold oscillations, coupling strength and delay time on the weak periodic signal detection. Results indicate that the delayed feedback either enhances or suppresses the weak signal detection depending on its parameters, when compared to that without the feedback. The delayed feedback augments the weak periodic signal detection for the optimal values of the intrinsic noise and the coupling strength when the delay time is close to the integer multiples of the period of the intrinsic oscillations, due to the multiple resonance among the weak signal, the intrinsic oscillations, and the delayed feedback.
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Citation Excerpt :
Synapses of this type are called autapses. Some of the neurons forming autapses are known to be inhibitory, see Chan-Palay (1971), Park et al. (1980) and Tamás et al. (1997) for experimental evidence. As a result, the neuron stimulates itself obtaining an inhibitory impulse through an autapse after each firing with some propagation delay.
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Recurrent inhibition in the rat neostriatum

Summary

Brain Research

Exp. Neurol.

Brain Research

Brain Research

Exp. Neurol.

Exp. Neurol.

Brain Research

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Brain Research

Brain Research

Brain Research

Brain Research