Denervation of the primary olfactory pathway in mice. V. Long-term effect of intranasal ZnSO4 irrigation on behavior, biochemistry and morphology
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2023, Trends in NeurosciencesCitation Excerpt :SARS-CoV-2 does not invade the olfactory nerve in patients with COVID-19, and this nerve remains largely intact during anosmia [22–24,27]. In animal models and also in humans, many regions of the olfactory epithelium retain half or more of their olfactory receptor neurons after inoculation or infection [22,28], which is thought to be more than sufficient to maintain a basic sense of smell [29–31]. Effects of the virus on axonal pathology in the olfactory bulb and cerebral cortex, whether directly by viral infection or indirectly through host immune responses, were not significantly different between patients with COVID-19 with loss of smell and patients without loss of smell [32].
Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice
2017, NeuroToxicologyCitation Excerpt :For the initial time course (0–24 h) all mice used were heterozygotes. Mice were dosed IN with 10 μL of 170 mM ZG per nostril at 8 wk of age under light isoflurane anesthesia This concentration of ZG was previously reported to induce robust damage to the olfactory epithelium, with subsequent recovery (Harding et al., 1978), and the volume was based on previous experience in our lab and recommendations of Dhuria et al. (2010). Mice were held at an approximately 45° angle from the horizontal position, with the head pointing to the floor.
Patterns of olfactory bulb neurogenesis in the adult zebrafish are altered following reversible deafferentation
2016, NeuroscienceCitation Excerpt :An alternative model of reversible deafferentation involves chemical ablation of the olfactory epithelium with a single application of Triton X-100, ZnSO4, or methyl bromide. These lesions also result in a reduction in olfactory bulb weight and volume (Margolis et al., 1974; Harding et al., 1978; Schwob et al., 1999) and a decrease in tyrosine hydroxylase expression (Nadi et al., 1981; Baker et al., 1983). Recovery of the mammalian olfactory epithelium is substantial but incomplete at 30 days post lesion, with mature neurons reaching near control numbers at 4–6 weeks (Schwob et al., 1995; Herzog and Otto, 1999; Cummings et al., 2000).
Methods and Models of the Nonmotor Symptoms of Parkinson Disease
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Current address: Dept. of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164.