Some observations on the binding patterns of α-bungarotoxin in the central nervous system of the rat
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Cited by (201)
Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats
2022, Brain Research BulletinCitation Excerpt :It is known that α7nAChR-dependent cholinergic signaling is implicated in suppressing the release of HMGB1 (Wang et al., 2004). For example, under inflammatory pain states, the application of agonist triggering α7nAChR signal effectively block the release of HMGB1 (Li et al., 2013), conversely, administration of α7nAChR inhibitor α-Bgtx can completely reverse this effect (Hunt and Schmidt, 1978). Suggesting that α7nAChR-HMGB1 signaling may be involved in modulating chronic inflammatory pain.
Cholinergic boutons are closely associated with excitatory cells and four subtypes of inhibitory cells in the inferior colliculus
2021, Journal of Chemical NeuroanatomyCitation Excerpt :Details of AChR subtype distribution in the IC is incomplete, but some differences between subdivisions are clear. For nicotinic receptors, α7 and β4 subunits are more prevalent in the ICc and α4 subunits are more prevalent in areas outside the ICc (Gahring et al., 2004; Happe and Morley, 2004; Hunt and Schmidt, 1978). For muscarinic receptors, M1 is distributed rather evenly whereas M2 and M3 are more prevalent in the areas outside ICc (Hamada et al., 2010; Levey et al., 1991; Spencer et al., 1986).
Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease
2015, Biochemical PharmacologyCitation Excerpt :α7 nAChRs are uniquely localized throughout the brain, although there is substantial overlap in their distribution with other nAChR subtypes. α7 nAChRs are very widespread, with a dense localization in regions such as the hypothalamus, geniculate nuclei, colliculi, hippocampus, medial habenula, thalamus, cortex, amygdala, and sparse expression in striatum, forebrain, medulla and various brain nuclei (Fig. 1) [23–29]. Consistent with their extensive CNS localization, α7 nAChRs are implicated in numerous functions including development, maintenance, survival, synaptic plasticity, neurotransmitter release and/or immune responsiveness.
α7 Nicotinic acetylcholine receptors and their role in cognition
2013, Brain Research BulletinCitation Excerpt :Cholinergic innervation of the rat parietal cortex and hippocampus does not predominantly synapse on to other neurons as demonstrated by electron microscopy studies (Umbriaco et al., 1994, 1995). On the receiving end, the existence of nAChRs at nonsynaptic sites is well established (Adams et al., 2001; Fabian-Fine et al., 2001; Graham et al., 2003; Hill et al., 1993; Horch and Sargent, 1995; Hunt and Schmidt, 1978; Kawai et al., 2002; Ullian and Sargent, 1995; Williams et al., 1998). Thus, nonsynaptically localised receptors are the main targets of ACh present in the extracellular space (Vizi, 2000; Lendvai and Vizi, 2008).
A phenotype for the α7 nicotinic acetylcholine receptor null mutant
2004, Brain ResearchCitation Excerpt :Muscarinic, rather than nicotinic, acetylcholine receptors probably mediate ACh actions in peripheral reproductive tissues [25,29]. The expression of α7 mRNA and α-bungarotoxin binding in rodent hypothalamus has been reported by several investigators [3,12,16,17,20,26]. The α7 nAChR is expressed in at least some brain regions regulated by gonadal hormones [3,4,18,21].
Olfactory System
2004, The Rat Nervous System
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Present address: MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Hills Road, Cambridge CB2 2QD, Great Britain.