The pharmacological and anatomical substrates of the amphetamine response in the rat

doi:10.1016/0006-8993(75)90834-3

Brain Research

Volume 83, Issue 3, 17 January 1975, Pages 419-436

https://doi.org/10.1016/0006-8993(75)90834-3 Get rights and content

Abstract

Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotorand stereotypy responses tod-amphetamine in adult rats. The lesions resulted in a depletion of over 99% of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine pathway) as well as severe noradrenaline depletions. However, lesion of the dorsal or ventral noradrenergic pathways resulted in similar noradrenaline depletions but with no effect on striatal tyrosine hydroxylase levels and without the concomitant blockage of the amphetamine response. The substantia nigra lesioned rats were behaviourally supersensitive to apomorphine andl-DOPA and did not show a locomotor response to cocaine. The substantia nigra lesioned rats were not aphagic or adipsic. It was concluded that both the locomotor and stereotyped responses induced by amphetamine are dependent on the functional integrity of the nigro-striatal dopamine pathway.

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^*: Present address: Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A.

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The pharmacological and anatomical substrates of the amphetamine response in the rat

Abstract

Brain Research

Brain Research

Europ. J. Pharmacol.

Brain Research

Exp. Neurol.

Physiol. Behav.

Brain Research

Brain Research

Europ. J. Pharmacol.

Neuropharmacology

Europ. J. Pharmacol.

Life Sci.

Brain Research

Neuropharmacology

Central decar☐ylation and uptake ofl-Dopa

Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.

Intrahypothalamic and intrastriatal dopamine and norepinephrine injections in relation to motor hyperactivity in rats

Psychopharmacologia (Berl.)

The direct demonstration of a barrier mechanism in the brain capillaries

Acta pharmacol. (Kbh.)

Norepinephrine: release from the brain byd-amphetaminein vivo

Science

Effects of amphetamine on the turnover rate of brain catecholamines and motor activity

Brit. J. Pharmacol.

Pharmacological implications of the effects of amphetamine and its analogs on the turnover rate of tissue catecholamine

Amphetamine response in rat after dopamine neurone destruction

Nature New Biol.

Neostriatum and functions of prefrontal cortex

Acta Neurobiol.