Morphine analgesia: Blockade by raphe magnus lesions
References (40)
- et al.
Monoaminergic mechanisms of stimulation-produced analgesia
Brain Research
(1975) - et al.
Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor
Brain Research
(1972) - et al.
Central monoamines and antinociceptive drug action
Europ. J. Pharmacol.
(1972) - et al.
Excitatory connection from lateral hypothalamic self-stimulation sites to escape sites in medullary reticular formation
Exp. Neurol.
(1970) - et al.
Morphine analgesia, two-way avoidance, and consummatory behavior following lesions in the midbrain raphe nuclei of the rat
Pharmacol. Biochem. Behav.
(1974) - et al.
Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis
Brain Research
(1974) - et al.
Sites of morphine induced analgesia in the primate brain: relation to pain pathways
Brain Research
(1974) - et al.
Influence of serotonin antagonists on bulbospinal systems
Brain Research
(1973) - et al.
New long latency bulbospinal evoked potentials blocked by serotonin antagonists
Brain Research
(1974) - et al.
Reduced effect of morphine in midbrain raphe lesioned rats
Europ. J. Pharmacol.
(1970)
Autoradiographic studies concerning the supraspinal site of the antinociceptive action of morphine when inhibiting the hindleg flexor reflex in rabbits
Neuropharmacology
Effect of 6-hydroxydopamine, 5,6-dihydroxytryptamine and raphe lesions on the antinociceptive actions of morphine in rats
Psychopharmacologia (Berl.)
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
J. Physiol. (Lond.)
Roles of noradrenaline and 5-hydroxytryptamine in the antinociceptive effects of morphine
Mechanism of phenylquinone writhing
Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems
Acta physiol. scand.
A method for determining loss of pain sensation
J. Pharmacol. exp. Ther.
The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests
J. Pharmacol. exp. Ther.
Opposed behavioral syndromes in rats with partial and more complete central serotonergic lesions made with 5,6-dihydroxytryptamine
Psychopharmacologia (Berl.)
An interaction between morphine and fenfluramine in mice
J. Pharm. Pharmacol.
Cited by (300)
New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum
2019, Chinese Journal of Natural MedicinesInflammatory mediators of opioid tolerance: Implications for dependency and addiction
2019, PeptidesCitation Excerpt :The PAG signals to RVM neurons, which then signal to the spinal cord to inhibit nociceptive dorsal horn neurons and produce antinociception[37–39]. Indeed, lesions of the RVM and spinal dorsal horn abolish PAG stimulation-produced antinociception, indicating that the PAG-RVM-spinal cord circuit is necessary for both exogenous and endogenous pain modulation [40,41]. In addition to being a critical locus for both endogenous and exogenous pain modulation, the vlPAG is critical for the development of morphine tolerance [24,42–51].
Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla
2016, Neuroscience LettersCitation Excerpt :The RVM has been proposed to play a crucial role in opioid antinociception, electrical stimulation-induced analgesia, and placebo-induced analgesia [3,19]. Electrical stimulation of the RVM results in powerful antinociception in experimental animals [21,24,38]. Similarly, microinjection of opioids into the RVM also results in antinociception [2,16,17,33].
Sex differences in connectivity of the subgenual anterior cingulate cortex
2014, PainCitation Excerpt :The PAG is engaged both by ascending projections from the spinal cord and by descending projections from the cortex. Structural and functional animal studies have repeatedly shown that the raphe nucleus is an important intermediary region between the spinal cord and PAG-mediating analgesia [1,8,12,13,15,16,21,22,42,55,58,78,80,82,86–88,92,93]. Accordingly, our findings suggest that women may be able to more strongly engage the descending pain modulation pathway, involving the PAG and raphe nucleus, than men.
Pain Pathways: Peripheral, Spinal, Ascending, and Descending Pathways
2013, Practical Management of Pain: Fifth EditionPain pathways
2013, Practical Management of Pain: Fifth Edition