Original articleProgrammed cell death: Implications for neuropsychiatric disorders☆
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2019, Journal of Biological ChemistryCitation Excerpt :Apoptosis is an essential homeostatic pathway mediating morphogenesis, development, and organismal protection against damaged or dangerous cells (for review, see Elmore (1)). Mis-regulation of apoptosis has been implicated in the progression of numerous multifactorial diseases, including cancer (low apoptotic activity) (2–5) or neurodegenerative disorders like Alzheimer's, Huntington's, and Parkinson's diseases during instances of heightened cell death (6–9). Briefly, caspases are divided into inflammatory (caspase-1, -4, and -5) or apoptotic classes.
Apoptosis as a mechanism of developmental neurotoxicity
2018, Handbook of Developmental NeurotoxicologyDo schizophrenia patients age early?
2014, Asian Journal of PsychiatryCitation Excerpt :The drawbacks of the gliosis hypothesis however are, firstly there is a lack of consistent methodology adopted across studies to determine the presence or absence of gliosis (Harrison, 1999). Secondly, proponents of neurodegenerative theories have suggested that the absence of gliosis and evidence of cell degeneration could be due to the fact that the pathophysiology involves a graded apoptosis rather than a fulminant necrotic process (Margolis et al., 1994). Apoptosis is a form of cell death that occurs in many neurodegenerative disorders in which intra- or extracellular physiologic events trigger a programmed sequence of cellular actions resulting in cell destruction and evacuation (Bredesen, 1995).
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Supported by a PRAT fellowship from the National Institute of General Medical Sciences.
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Dr. Margolis is now with the Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD.