CommentaryRegulation of angiogenesis: A new function of heparin
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Pharmacological and clinical application of heparin progress: An essential drug for modern medicine
2021, Biomedicine and PharmacotherapyCitation Excerpt :Thus, blocking angiogenesis is a very promising strategy for treating tumors [178]. Consequently, heparin was shown to inhibit angiogenesis as early as 1985 [179,180]. More studies exist on LMWH inhibiting angiogenesis.
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2017, Sclerotherapy: Treatment of Varicose and Telangiectatic Leg VeinsMutually Supportive Mechanisms of Inflammation and Vascular Remodeling
2016, International Review of Cell and Molecular BiologyCitation Excerpt :Histamine receptor antagonists have antiangiogenic properties in vitro in assays in HUVECs and human pulmonary artery endothelial cells, and in vivo in chick embryo chorioallantoic membrane assay (De Luisi et al., 2009; Kubecova et al., 2011). Heparin release from granules stimulates endothelial chemotaxis and migration, and protects bFGF from degradation (Folkman, 1985). In addition to asthma associated angiogenesis, mast cells also drive angiogenesis and lymphangiogenesis in tumors.
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2011, SclerotherapyLow molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat
2007, Journal of HepatologyCitation Excerpt :Heparin is a glycosaminoglycan with repeating sequences of d-glucuronic acid and N-acetyl-d-glucosamine [9]. Besides its well-known function as an anticoagulant [9,10], heparin has been shown to possess a variety of physiological and pharmacological properties including anti-inflammatory/allergic reactions [11,12], inhibition of angiogenesis [13,14], and prevention of tumor growth and metastasis [15,16]. Conventional unfractionated heparin preparations are of a heterogeneous mixture of molecules with molecular weight (MW) ranging from 3000 to 30,000 Da [10].