Elsevier

Biochemical Pharmacology

Volume 31, Issue 7, 1 April 1982, Pages 1251-1255
Biochemical Pharmacology

Inhibition of rat liver monoamine oxidase by α-methyl- and N-propargyl-amine derivatives

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Abstract

The inhibition of rat liver monoamine oxidase by a number of N-propargyl and α-methyl amine derivatives has been examined. The results indicate that α-methyl-substituted primary and secondary amine derivatives tend to show selectivity as reversible inhibitors towards the A-form of the enzyme. The structural features that result in selectivity in irreversible inhibitors are less easy to define and substitution of an N-propargyl group into a compound that is a selective reversible inhibitor of monoamine oxidase will not necessarily result in retention of that selectivity. Replacement of the acetylenic group in a B-selective irreversible inhibitor by an ethylenic group resulted in a compound that was a reversible inhibitor showing slight selectivity for the A-form of the enzyme.

References (36)

  • M.D. Houslay et al.

    Life Sci.

    (1976)
  • F.M. Achee et al.

    Prog. Neurobiol.

    (1977)
  • J.P. Johnston

    Biochem. Pharmac.

    (1968)
  • C.J. Fowler et al.

    Biochem. Pharmac.

    (1978)
  • J. Mann et al.

    Life Sci.

    (1980)
  • T.J. Mantle et al.

    Biochem. Pharmac.

    (1976)
  • S. Otsuka et al.

    Biochem. Pharmac.

    (1964)
  • J. Knoll et al.

    Biochem. Pharmac.

    (1978)
  • J. Knoll et al.

    Adv. Biochem. Psychopharmac.

    (1972)
  • J.A. Herd

    Clin. Trials

    (1969)
  • D. Wheatley

    Br. J. Psychiat.

    (1970)
  • D.L. Murphy et al.

    Monoamine Oxidase Inhibitors. The State of the Art

  • M. Mendis et al.

    Monoamine Oxidase Inhibitors. The State of the Art

  • J. Mendlewicz et al.

    Monoamine Oxidase Inhibitors. The State of the Art

  • W. Birkmayer et al.

    J. Neural Transm.

    (1975)
  • W. Birkmeyer et al.

    Lancet

    (1977)
  • M. Yahr

    J. Neural Transm.

    (1978)
  • Cited by (0)

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