Antiporphyric activity of theophylline in normal and allylisopropylacetamide-treated rats

doi:10.1016/0006-2952(78)90548-8

Biochemical Pharmacology

Volume 27, Issue 13, 1978, Pages 1729-1730

https://doi.org/10.1016/0006-2952(78)90548-8 Get rights and content

Abstract

Theophylline decreases the levels of 5-aminolevulinic (ALA) synthetase in allylisopropylacetamide(AIA)-treated rats. Since theophylline increases cell cAMP levels this result suggests cAMP involvement in ALA synthetase repression. Theophylline in AIA-treated rats also protects the levels of cytochrome P-450 which reflect the values of total heme, the natural repressor of ALA synthetase activity.

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Cited by (1)

Drug therapy in the acute porphyrias
1985, Clinics in Dermatology
The thrust of this chapter will be on drug therapy in the acute porphyrias. Specifically, avoidance of those drugs that might precipitate an acute neurologic episode or “acute attack” will be discussed. In the realm of the dermatologist, this will apply to patients with one of two disorders: variegate porphyria (South African genetic porphyria, VP) and hereditary coproporphyria (HC). The third of the acute porphyrias, acute intermittent porphyria (AIP), is not associated with skin lesions and such patients are accordingly unlikely to consult a dermatologist. In this chapter, we shall neither deal with the important topic of drug therapy during an acute attack nor precipitation or treatment by drugs of the purely cutaneous porphyrias; these subjects will be addressed elsewhere in this volume.

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Antiporphyric activity of theophylline in normal and allylisopropylacetamide-treated rats

Abstract

Archs Biochem. Biophys.

Lancet

J. biol. Chem.

Biochim. biophys. Acta

J. biol. Chem.

J. biol. Chem.

Archs Biochem. Biophys.

J. biol. Chem.

S. Afr. J. Lab. clin. Med.