A chemical basis for the antitumor activity of chloroethylnitrosoureas
References (20)
- et al.
Biochem. biophys. Res. Commun.
(1974) - et al.
Biochem. biophys. Res. Commun.
(1974) - et al.
J. pharm. Sci.
(1965) - et al.
Biochem. biophys. Res. Commun.
(1973) - et al.
Cancer Res.
(1876) - et al.
- et al.
Cancer Chemother, Rep.
(1970) - et al.
Cancer Res.
(1963) - et al.
Cancer Chemother. Rep.
(1965) - et al.
Cancer Res.
(1973)
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2014, Critical Reviews in Oncology/HematologyCitation Excerpt :These agents are mainly used for the treatment of brain tumors, melanomas, and some carcinoid tumors (Table 2). Their mechanism of action relies on the formation of diazohydroxyde in basic conditions, that in turn generates a reactive cation responsible for alkylation which takes place primarily on O6 or N7 positions of guanines (Fig. 9B) [3,33,34,36]. O6G alkylation by carmustine is described in Fig. 9B. First, a chloroethylated adduct is generated and is followed by the formation of a N1G:N3C inter-strand cross-link [3,33,34,37] (Fig. 9B).
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2010, Archives of Biochemistry and BiophysicsCitation Excerpt :Chloroethylnitrosoureas (CENUs)1 are chemotherapeutic agents used in clinical treatment of different types of cancers [1]. In order to become potent cytotoxic compounds CENUs must be converted into electrophilic products that can alkylate macromolecules [2–4]. This occurs by spontaneous decomposition of the compounds in aqueous media.
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