Elsevier

Biochemical Pharmacology

Volume 23, Issue 13, 1 July 1974, Pages 1817-1825
Biochemical Pharmacology

Effects of Δ9-tetrahydrocannabinol on the levels of cyclic adenosine 3',5'-monophosphate in mouse brain

https://doi.org/10.1016/0006-2952(74)90190-7Get rights and content

Abstract

The effects of intraperitoneal injections of various doses of Δ9-tetrahydrocannabinol (Δ9-THC) on brain levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been studied in mice. Doses of Δ9-THC in the range of 0.1 to 1.0 mg/kg cause a 50–160 per cent elevation of cyclic AMP levels compared to controls (P < 0.0005), while doses of Δ9-THC in the range of 2.0 to 10.0 mg/kg cause a 30–60 per cent depression of cyclic AMP levels (P = 0.025 to 0.0005). This pattern was obtained in whole brain, as well as in dissected samples of cortex, cerebellum and medulla. This over-all biphasic effect of THC on cyclic AMP levels correlates with known changes in biogenic amines, temperature regulation, and behavior caused by this drug.

References (51)

  • B.T. Ho et al.

    Brain Res.

    (1972)
  • B.T. Ho et al.

    Brain Res.

    (1971)
  • L.M. Klainer et al.

    J. biol. Chem.

    (1962)
  • M.J. Schmidt et al.

    Brain Res

    (1972)
  • A.L. Koch et al.

    Analyt. Biochem.

    (1971)
  • E. Miyamoto et al.

    J. biol. Chem.

    (1969)
  • M.M. Appleman et al.

    Archs Biochem. Biophys.

    (1966)
  • G.I. Drummond et al.

    J. biol. Chem.

    (1970)
  • Y.H. Abdulla et al.

    Lancet

    (1970)
  • M.I. Paul et al.

    Lancet

    (1970)
  • R.D. Sofia et al.

    Eur. J. Pharmac.

    (1971)
  • S.H. Burstein et al.

    Nature, Lond.

    (1970)
  • H.D. Christensen et al.

    Science, N.Y.

    (1971)
  • R.L. Foltz et al.

    Science, N.Y.

    (1970)
  • M. Galanter et al.

    Science, N.Y.

    (1972)
  • Y. Gaoni et al.

    J. Am. chem. Soc.

    (1964)
  • L.E. Hollister

    Science, N.Y.

    (1971)
  • E. Hollister et al.

    Clin. Pharmac. Ther.

    (1968)
  • H. Isbell et al.

    Psychophuarmacologia

    (1967)
  • L. Lemberger et al.

    Science, N.Y.

    (1971)
  • L. Lemberger et al.

    Science, N.Y.

    (1972)
  • R. Mechoulam et al.

    Science, N.Y.

    (1970)
  • R. Mechoulam

    Science, N.Y.

    (1970)
  • I.M. Nilsson et al.

    Science, N.Y.

    (1970)
  • M. Perez-Reyes et al.

    Science, N.Y.

    (1972)
  • Cited by (19)

    View all citing articles on Scopus

    Supported in part by Grant 5RO1 DA00116 (formerly MH 21003) from the National Institute of Mental Health.

    View full text