Elsevier

Biochemical Pharmacology

Volume 22, Issue 1, 1 January 1973, Pages 67-72
Biochemical Pharmacology

Isosorbide, isomannide and isoidide dinitrate: Urinary excretion in the rat

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Abstract

In rats given the dinitrates of isosorbide, isomannide and isoidide orally, urinary excretion products were studied by gas chromatography and thin layer chromatography. The unchanged dinitrates are excreted in small amounts; the different mononitrates and denitrated alcohols are also present; the mononitrates are conjugated to a large extent. After administration of isosorbide dinitrate, isoidide mononitrate and isoidide are excreted in the urine, and after isomannide dinitrate administration, 5-isosorbide mononitrate and isosorbide can be found. This inversion of configuration from the endo- to the exo-position could be due to the formation of a carbonyl intermediate or to a backside displacement mechanism.

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