Elsevier

Biochemical Pharmacology

Volume 20, Issue 9, September 1971, Pages 2429-2437
Biochemical Pharmacology

The metabolism of S-(1,2 Dichlorovinyl)-l-cysteine by rat liver mitochondria

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Abstract

Isolated rat liver mitochondria degrade DCVC to pyruvic acid and ammonia. Another metabolite of unknown structure qualitatively possesses the characteristics of an alkylating agent. Pyridoxal 5'-phosphate catalyses the non-enzymic breakdown of DCVC to pyruvic acid and ammonia. Semicarbazide, a pyridoxal 5'-phosphate trapping reagent blocks the metabolism of DCVC by rat liver mitochondria. This metabolism of DCVC by rat liver mitochondria is judged to be relevant to the inhibition of respiration of rat liver mitochondria which is delayed in onset and which was reported in the preceding paper.

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