Biochemical and Biophysical Research Communications
Cloning and functional characterization of a human Al adenosine receptor
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2020, European Journal of PharmacologyDesign, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A<inf>2A</inf> adenosine receptor ligands
2019, European Journal of Medicinal ChemistryCaffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1
2016, Molecular and Cellular NeuroscienceCitation Excerpt :Adenosine, a byproduct of adenosine triphosphate ATP metabolism, is a potent inhibitory neuromodulator that acts through increasing postsynaptic K+ conductance and decreasing presynaptic Ca2 + conductance (Trussell and Jackson, 1985; Gerber et al., 1989; Greene and Haas, 1991; Newman, 2003). Therefore, elevation of extracellular adenosine levels during sleep deprivation causes activation of the Gi protein coupled adenosine A1 receptor (Libert et al., 1992; Olah and Stiles, 1995) leading to reduction of transmitter release of surrounding excitatory presynaptic terminals. Being an adenosine receptor antagonist, caffeine counteracts the inhibitory effects of adenosine in the brain, which explains caffeine's well-known beneficial effects during sleep loss.
The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity
2012, Cellular SignallingCitation Excerpt :Another hint that caffeine may indeed act on the cAMP-PKA pathway came from recent work in flies [113], which found that caffeine reduced and fragmented sleep in flies, and that those effects were mitigated in flies with reduced PKA activity. Caffeine could also prevent the effects of sleep deprivation on memory and plasticity by antagonizing adenosine receptors (reviewed in [112]), which inhibit cAMP signaling through coupling to Gi proteins [114,115]. This is a particularly interesting possibility, given the role of adenosine signaling in the impairments in plasticity and memory induced by sleep deprivation as discussed in detail below.