Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (FcγR-I or CD64)

doi:10.1016/0006-291X(90)92131-I

Biochemical and Biophysical Research Communications

Volume 170, Issue 2, 31 July 1990, Pages 582-588

https://doi.org/10.1016/0006-291X(90)92131-I Get rights and content

Abstract

Immune interferon (IFN-γ) induces in human neutrophils accumulation of the mRNA for the high affinity receptor for monomeric IgG (FcγR-I, CD64) with a mechanism that is independent from de novo protein synthesis and from activation of the $Na^{+} H^{+}$ antiporter. Monocyte-derived macrophages can also be induced to express high levels of FcγR-I mRNA by IFN-γ, without requirement of protein synthesis. Unlike what is observed in neutrophils, induction by IFN-γ of macrophage FcγR-I mRNA was significantly depressed by the $Na^{+} H^{+}$ antiporter inhibitor amiloride. These results indicate that phagocytes' FcγR-I mRNA induction by IFN-γ is regulated by different mechanisms depending on the target cells.

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Citation Excerpt :
Second, the kinetics of a prospective marker should be considered along with its sensitivity and specificity because a rapid increase of the marker would allow a good discrimination between health and disease. In this sense, other authors have demonstrated that PMN CD64 upregulation occurs in the short time scale of 4–6 h for cell surface expression and 1–3 h for detectable mRNA increases by northern blot analysis.35,45–48 PMN CD64 upregulation is induced by inflammatory-related cytokines, such as granulocyte colony-stimulating factor (G-CSF) and interferon (IFN)-γ.49
We performed a systematic review and meta-analysis of studies to evaluate the diagnostic accuracy of expression of CD64 on polymorphonuclear neutrophils (PMN) as a marker for bacterial infection.
The analysis included studies of patients from all age groups that prospectively evaluated CD64 expression on PMNs for the diagnosis of bacterial infection. We evaluated the methodological quality of the studies according to the 25-item criteria developed by the Standards for Reporting of Diagnostic Accuracy (STARD) committee. We calculated a summary receiver operating characteristic (SROC) curve across studies included in the meta-analysis.
The methodological quality score of the 13 included studies ranged from 9 to 16 points (maximum score was 25 points). The pooled sensitivity and specificity for CD64 expression on PMNs were 79% (95% CI: 70–86%) and 91% (95% CI: 85–95%), respectively. The area under curve (AUC) was 0.94.
On the basis of this meta-analysis, CD64 expression on PMNs could be a useful diagnostic cell-based parameter of bacterial infections. However, published studies about this topic showed a low methodological quality.
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Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (FcγR-I or CD64)

Abstract

Immunol. Today

Meth. Enzymol

Biochem. Biophys. Res. Commun

Biochem. Biophys. Res. Commun

Blood

Kidney International

Nature (Lond.)

J. Immunol

Immunology

J. Exp. Med