Apparent sequence preference in cleavage of linear B-DNA by the Cu(II): Thiol system

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Abstract

Cleavage of a linear tyr T fragment of duplex DNA by Cu(II): thiol combinations occurs with apparent sequence preference. The sequence selectivity was unaffected by the size, chirality or substitution pattern of the monothiol partner, presumably indicating that the Cu(II): RSH system is probing some local conformational/dynamic aspect of the DNA.

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