Biochemical and Biophysical Research Communications
Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells
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Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A
2017, NeuronCitation Excerpt :This may explain, for example, why activation of the designer receptor hM3Dq increases PKA activity in the hippocampus (Figures 7C, 7D, and S8C–S8H), but not in COS7 or pancreatic β cells (Guettier et al., 2009). Thus, the cell-type specificity conferred by molecular components may explain seemingly conflicting observations and mechanisms across different cell lines and cell types (Bandrowski et al., 2001; Baumgold and Fishman, 1988; Onali and Olianas, 1990; Wang et al., 2008) and could give rise to functional specificity to Gαq signaling in different cell types and subcellular compartments. PKA phosphorylates many neurotransmitter receptors, ion channels, and transcription factors and is associated with synaptic plasticity (Esteban et al., 2003; Higley and Sabatini, 2010; Kandel and Abel, 1995; Lerner and Kreitzer, 2011; Seol et al., 2007; Shen et al., 2008; Skeberdis et al., 2006; Woolfrey and Dell’Acqua, 2015; Yasuda et al., 2003).
The cholinergic immune regulation mediated by a novel muscarinic acetylcholine receptor through TNF pathway in oyster Crassostrea gigas
2016, Developmental and Comparative ImmunologyCitation Excerpt :It has been announced that the intracellular Ca2+ fluxes would enhance once M1, M3 and M5 muscarinic receptors were activated (Berridge, 1993; Elaev et al., 1984; Felder, 1995; Hulme et al., 1990). cAMP accumulation also occurred in neuroblastoma cells when the M3 mAChR pathway was triggered (Baumgold and Fishman, 1988). The phylogeny analysis indicated that CgmAChR-1 might be one of the M5 muscarinic receptors, and the present biological validation using antagonists further implied that CgmAChR-1 might be M3 or M5 subtypes.
The role of intracellular pathways in the proliferation of human K562 cells mediated by muscarinic receptors
2013, Leukemia ResearchCitation Excerpt :The M2 and the M4 subtypes can express only a modest stimulation of phosphoinositide (PI) hydrolysis when overexpressed in some cell types [1,18–21]. Furthermore, the endogenous M3 subtype can cause an accumulation of cAMP in distinct cell types [22–24]. The coupling of muscarinic receptors to adenylyl cyclase activation can also be regulated through calcium and protein kinase mechanisms [25,26].
Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons
2012, NeuropharmacologyCitation Excerpt :Importantly, M1 receptors are shown to increase cAMP formation in striatal slices (Sanchez-Lemus and Arias-Montano, 2006). Several mechanisms for the action of M1 receptors such as activation of the Gq/11/PLC/PKC signaling pathway (Baumgold and Fishman, 1988; Felder et al., 1989; Jansson et al., 1991) and coupling to Gαs or adenylyl cyclase (Gurwitz et al., 1994; Burford and Nahorski, 1996) have been proposed. We have previously reported that activation of mGluR5 induces the increase in PKA/DARPP-32 signaling via potentiation of adenosine A2A receptor signaling (Nishi et al., 2003, 2005).