Transport of glutathione by renal basal-lateral membrane vesicles
References (10)
- et al.
FEBS Lett
(1979) - et al.
J. Surg. Res
(1976) - et al.
Biochem. Biophys. Res. Commun
(1980) - et al.
Biochem. Biophys. Res. Commun
(1980) - et al.
FEBS Lett
(1982)
Cited by (75)
Renal Glutathione: Dual roles as antioxidant protector and bioactivation promoter
2024, Biochemical PharmacologyTrichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity
2014, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Renal plasma DCVG can be a substrate for one of three putative carriers on the basolateral plasma membrane. Work by Lash and Jones [163,164] defined the processes of basolateral GSH uptake, demonstrating energy-dependent and both Na+-coupled and Na+-independent transport. They further showed that, like many membrane transporters, these carriers have somewhat broad substrate specificities and can also transport various γ-glutamyl amino acids and GSH S-conjugates, including DCVG [165].
Glutathione transporters
2013, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Based upon experimental evidences from many studies, two main mechanisms of glutathione uptake into the mammalian cells may be operating. Biochemical studies have shown the existence of Na+ dependent and Na+ independent glutathione transport systems in different tissues such as renal basolateral membrane [20,59], small intestine [18], and brain cells [60]. The uptake of the GSH molecule into renal proximal tubular cells occurred despite the irreversible inhibition of γ-GT by acivicin [20,59], providing strong evidence for existence of a transport system to take up intact glutathione molecule in the kidney cells.
Targeting maladaptive glutathione responses in lung disease
2011, Biochemical PharmacologyCytoprotective Systems within the Kidney
2010, Comprehensive Toxicology, Second EditionAmino Acids, Oligopeptides, and Hyperaminoacidurias
2008, Seldin and Giebisch's The Kidney