Ethylisopropyl-amiloride: A new and highly potent derivative of amiloride for the inhibition of the Na+H+ exchange system in various cell types

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Abstract

Ethylisopropyl-amiloride is 100 times more potent than amiloride for inhibiting the Na+H+ exchanger of 3T3 fibroblasts, chick skeletal muscle cells and chick cardiac cells. Half-maximum effects, measured at 3 mM external Na+ are observed at 20–100 nM and 5 μM for ethylisopropyl-amiloride and amiloride respectively. As previously observed for amiloride, the effect of ethylisopropyl-amiloride is antagonized by external Na+ ions.

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