Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin
References (42)
- et al.
J. Biol. Chem
(1985) - et al.
Exp. Cell. Res
(1981) - et al.
Beitr. Pathol
(1973) Cell
(1981)- et al.
J. Biol. Chem
(1982) - et al.
- et al.
Arch. Biochem. Biophys
(1984) - et al.
J. Biol. Chem
(1951) - et al.
Exp. Cell Res
(1981) Biochim. Biophys. Acta
(1984)
Exp. Cell Res
Toxicol. Lett
J. Biol. Chem
Pathol. Res. Pract
Science
Nature (London)
Surv. Synth. Pathol. Res
J. Cell. Biol
Lab. Invest
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Screening and characterization of an Agrobacterium tumefaciens mutant strain producing high level of coenzyme Q<inf>10</inf>
2015, Process BiochemistryCitation Excerpt :The inhibitors included menadione (a structural analog of CoQ10) and sodium azide (a cytochrome c oxidase inhibitor). The cytotoxic effects of menadione have been extensively studied in whole liver and isolated hepatocytes, in which menadione decreases intracellular thiols, modifies intracellular Ca2+ homeostasis, and causes cell death [22–24]. On the other hand, sodium azide blocks the normal path of electrons in the electron transport chain, preventing the transfer of electrons from cytochrome a3 to oxygen, the final acceptor in the chain; it is also known as an inhibitor of catalase and a nitric oxide donor [25].
Molecular Mechanisms of Toxic Cell Death: An Overview
2013, In Vitro Toxicity IndicatorsMorphological and Biochemical Investigations on Plasma Membrane Blebbing during Cell Injury
2013, In Vitro Toxicity IndicatorsAllicin modulates the antioxidation and detoxification capabilities of primary rat hepatocytes
2012, Journal of Traditional and Complementary MedicineCitation Excerpt :An early visible indication of severe cell disturbance is the appearance of blebs on the outer surface of cell membrane (Lemasters et al., 1987; Simonin et al., 2007), which is not accompanied by immediate cell disruption (Scharfenberg et al., 1994). It was suggested that thiol oxidation of cytoskeleton proteins (Mirabelli et al., 1988) and plasma membrane rigidity (Florine-Casteel et al., 1991; Abe et al., 2009) might be intimately connected to, or precede, bleb formation. In our study, bleb formation and cell aggregation were observed 8 and 24 h after 50 μM allicin treatment.
Ineffective GSH regeneration enhances G6PD-knockdown Hep G2 cell sensitivity to diamide-induced oxidative damage
2009, Free Radical Biology and Medicine