The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase☆
References (26)
- et al.
Biochem. Biophys. Res. Commun
(1982) - et al.
Biochem. Biophys. Acta
(1981) - et al.
J. Biol. Chem
(1982) - et al.
J. Biol. Chem
(1975) - et al.
Biochem. Biophys. Res. Commun
(1981) - et al.
J. Biol. Chem
(1976) - et al.
- et al.
Anal. Biochem
(1980) - et al.
Tetrahedron Lett
(1982) - et al.
Biochem. Pharmacol
(1980)
J. Biol. Chem
Mutat. Res
Cited by (181)
Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
2023, Progress in Lipid ResearchThe challenges of treating osteoarthritis pain and opportunities for novel peripherally directed therapeutic strategies
2022, NeuropharmacologyCitation Excerpt :The epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) following oxidisation via the CYP450 pathway (Roman, 2002; Zeldin, 2001), and are of increasing interest due to their anti-inflammatory and anti-nociceptive effects. EETs are also short-lived in vivo, being rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH) into their respective diols (Chacos et al., 1983). Like the SPMs, the EETs have significant anti-inflammatory effects (Bystrom et al., 2011, 2013; Fleming, 2007), mediated by inhibition of NF-κβ nuclear translocation, thereby inhibiting the downstream production of pro-inflammatory cytokines (Node et al., 1999).
Prostaglandins and other lipid mediators cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
2020, Prostaglandins and Other Lipid MediatorsCitation Excerpt :In the case of the CYP2J, it has been demonstrated that the oxidation of ARA to 14,15-EET is preferred over other regioisomers [27]. The EETs are subsequently hydrolyzed by the sEH (Fig. 1) [28]. The sEH enzyme is a major regulatory enzyme for all the EpFAs converting them into corresponding vicinal diols, specifically for EETs into the dihydroxytrienoic acids (DHETs) which lack the biological function of EETs.
Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective
2019, Pharmacology and TherapeuticsThe arachidonic acid monooxygenase: From biochemical curiosity to physiological/pathophysiological significance
2018, Journal of Lipid Research
- ☆
Supported in part by grants from the National Institutes of Health (NIGMS 16488) and (NIEHS 5 R01 ES02710) and the Robert A. Welch Foundation (I-782). B.D.H. was supported by an NIEHS Research Career Development Award (ES 00107).