Case reportCyclosporine-associated central neurotoxicity after heart transplantation
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Long-term cyclosporine A treatment promotes anxiety-like behavior: Possible relation with glutamate signaling in rat hippocampus
2022, Journal of Affective Disorders ReportsCitation Excerpt :Despite the expected action on the immune system, CsA long-term treatment is associated with adverse effects that have deleterious outcomes on patients’ quality of life and survival (Magnasco et al., 2008). One of the most prominent adverse effects of CsA administration is neurotoxicity, which is responsible for neuropsychological problems, including anxiety, depression, headaches, tremor, hallucinations, and seizures (Batinić et al., 2017; Bechstein, 2000; Martinez, 1998; McManus et al., 1992; Pflugrad et al., 2018; Serkova et al., 2004). However, the clinical predisposition and mechanisms of CsA-induced neurotoxicity remain controversial and poorly understood.
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