Experimental study
Comparison of chronic and acute effects of morphine sulfate on cardiovascular function

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Abstract

Circulatory effects of morphine sulfate on supine anesthetized dogs were investigated to define acute and chronic effects of this drug upon cardiovascular function. Right atrial injection of morphine produced a sustained fall of systemic pressure, cardiac output and heart rate without a significant change in systemic resistance. The mechanism of its efficacy in treatment of acute pulmonary edema may be due to two major factors: (1) peripheral venous pooling of blood resulting in pulmonary decongestion which appears to be a short-lasting effect, and (2) a sustained decrease in left ventricular minute work with no apparent change in myocardial contractility, as demonstrated in this study.

N-allylnormorphine abolished the morphineinduced bradycardia but not the reduced cardiac output and systemic pressure.

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This work was supported in part by grants from the Life Insurance Medical Research Fund, the National Heart Institute, U. S. Public Health Service (Grants HE-00450, HTS-5234 and HTS-5550), the American Heart Association and the Godfrey Hyams Trust.

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