Abstract
Theiler’s murine encephalomyelitis virus infection of C57BL/6 mice results in acute behavioral seizures in 50% of the mice. Treatment of infected mice with minocycline or infection of interleukin (IL)-6-deficient chimeric mice results in a significant decrease in the number of mice developing seizures. However, in those mice that do develop seizures, the pathological changes (neuronal cell loss, inflammation [perivascular cuffing, gliosis, activated microglia/macrophages]), and the numbers of virus infected cells in minocycline-treated or IL-6-deficient chimeric mice are very similar. Therefore, once seizures develop, the pathological changes are consistent regardless of the treatment or genetic background.
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Acknowledgements
We thank Daniel J. Doty, Braden T. McElreath and Jordan T. Sim for technical assistance. We acknowledge Kathleen Borick for manuscript preparation.
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Libbey, J.E., Kennett, N.J., Wilcox, K.S. et al. Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6. J. Neurovirol. 17, 496–499 (2011). https://doi.org/10.1007/s13365-011-0050-5
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DOI: https://doi.org/10.1007/s13365-011-0050-5