Abstract
Recent population studies provide clues that the use of curcumin may be associated with reduced incidence and improved prognosis of certain cancers. In the present study, we demonstrated that curcumin acted as a growth inhibitor for lung cancer cells. Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. These findings provide evidence for a mechanism that may contribute to the antineoplastic effects of curcumin and justify further work to explore potential roles for activators of FOXO1 in the prevention and treatment of lung cancer.
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This study was supported by the National Natural Science Foundation of China (No. 81071839), Capital Medical Development Foundation of China (2007-2040).
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The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.
An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.
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Li, ZC., Zhang, LM., Wang, HB. et al. RETRACTED ARTICLE: Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1. Tumor Biol. 35, 111–116 (2014). https://doi.org/10.1007/s13277-013-1013-7
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DOI: https://doi.org/10.1007/s13277-013-1013-7