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Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study

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Abstract

People with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia.

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Authors and Affiliations

  1. Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, 100096, China

    Feng-Mei Fan, Shu-Ping Tan, Fu-De Yang, Yun-Long Tan, Yan-Li Zhao, Nan Chen, Bin-Bin Li, Chong-Sheng Song, Yun-Hui Wang & Yi-Zhuang Zou

  2. Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China

    Feng-Mei Fan & Xi-Nian Zuo

  3. Magnetic Resonance Imaging Unit, The 306th Hospital of PLA, Beijing, 100091, China

    Zhen Jin

  4. Institute of Mental Health, Peking University, Beijing, 100191, China

    Dong-Feng Zhou

  5. Center for the Developing Brain, Child Mind Institute, New York, NY, 10022, USA

    Michael P. Milham

  6. Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA

    Michael P. Milham

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  1. Feng-Mei Fan
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Fan, FM., Tan, SP., Yang, FD. et al. Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study. Neurosci. Bull. 29, 59–74 (2013). https://doi.org/10.1007/s12264-013-1300-8

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