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Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patients

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Abstract

Background

The relationship between breast cancer and circadian rhythm variation has been extensively studied. Increased breast tumorigenesis has been reported in melatonin-suppressed experimental models and in observational studies.

Objectives

Circulating Tumor Cells (CTC) circadian-rhythm may optimize the timing of therapies. This is a prospective experimental study to ascertain the day-time and night-time CTC levels in hospitalized metastasic breast cancer (MBC) patients.

Material and methods

CTC are isolated and enumerated from a 08:00 AM and 08:00 PM blood collections. 23 MBC and 23 healthy volunteers entered the study. 69 samples were collected (23 samples at 08:00 AM and 23 samples at 08:00 PM from MBC; 23 samples from healthy volunteers). Results from two patients were rejected due to sample processing errors. No CTC were isolated from healthy-volunteers.

Results and discussion

No-differences between day-time and night-time CTC were observed. Therefore, we could not ascertain CTC circadian-rhythm in hospitalized metastasic breast cancer patients.

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Correspondence to José Ángel García-Sáenz.

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García-Sáenz, J.Á., Martin, M., Maestro, M. et al. Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patients. Clin Transl Oncol 8, 826–829 (2006). https://doi.org/10.1007/s12094-006-0139-0

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  • DOI: https://doi.org/10.1007/s12094-006-0139-0

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