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G protein-coupled receptor 30 in tumor development

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Abstract

Estrogen plays several important physiological and pathological functions in not only reproductive system but many other systems as well. Its transcriptional activation has been traditionally described as being mediated by classic nuclear estrogen receptors (ERs). It is however established recently that a novel functional estrogen transmembrane receptor, G protein-coupled receptor 30 (GPR30), modulates both rapid non-genomic events and genomic transcriptional events of estrogen. It has been demonstrated that GPR30 promotes the progress of estrogen-related tumors through mitogen-activated protein kinase (MAPK) signaling pathways. Effects mediated by GPR30 are maintained when classic ERs are absent or blocked. In addition, GPR30 is involved in drug resistance, which is often occurring during cancer treatments. All these new findings strongly imply that GPR30 may be an important therapeutic target for estrogen-related tumors. Simultaneously blocking both GPR30 and classic ERs may be a better strategy for the treatment of estrogen-related tumors.

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Acknowledgment

Work in this laboratory is supported by Australian NHMRC, University of Queensland. DF Wang is a recipient of postgraduate research scholarship from the Chinese Scholarship Council (CSC, China) and subsidy scholarship by the University of Queensland. Authors would like to acknowledge editorial help of M. Sinclair.

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Authors and Affiliations

  1. Department of Gynecological Oncology, Second People’s Hospital of Sichuan (Sichuan Cancer Hospital), Sichuan, 610041, People’s Republic of China

    Dengfeng Wang & Guonan Zhang

  2. School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia

    Dengfeng Wang, Lin Zhang & Chen Chen

  3. Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Sichuan, 610041, People’s Republic of China

    Lina Hu

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  1. Dengfeng Wang
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  2. Lina Hu
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  3. Guonan Zhang
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  4. Lin Zhang
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Correspondence to Chen Chen.

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Wang, D., Hu, L., Zhang, G. et al. G protein-coupled receptor 30 in tumor development. Endocr 38, 29–37 (2010). https://doi.org/10.1007/s12020-010-9363-z

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  • DOI: https://doi.org/10.1007/s12020-010-9363-z

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