In vitro radioligand assay revealed interaction of afobazole with σ1-receptors (Ki=5.9 × 10—6 M). Translocation of σ1-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10—8 M.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 7, pp. 53-55, July, 2009
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Seredenin, S.B., Antipova, T.A., Voronin, M.V. et al. Interaction of Afobazole with σ1-Receptors. Bull Exp Biol Med 148, 42–44 (2009). https://doi.org/10.1007/s10517-009-0624-x
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DOI: https://doi.org/10.1007/s10517-009-0624-x