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Cardiac sympathetic denervation preceding motor signs in Parkinson disease

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Abstract

There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.

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Acknowledgements

This research was supported by the Intramural Research Program of the NIH, National Institute of Neurological Disorders and Stroke.

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Authors and Affiliations

  1. Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, Bethesda, MD, 20892-1620, USA

    David S. Goldstein MD, PhD, Yehonatan Sharabi MD, Oladi Bentho, Ahmed Saleem MD & Graeme Eisenhofer PhD

  2. Clinical Neurosciences Program, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA

    Barbara I. Karp MD

  3. Reproductive Biology and Medicine Branch, National Institute of Child Health and Development, NIH, Bethesda, MD, USA

    Karel Pacak MD, PhD

Authors
  1. David S. Goldstein MD, PhD
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  2. Yehonatan Sharabi MD
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  3. Barbara I. Karp MD
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  4. Oladi Bentho
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  5. Ahmed Saleem MD
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  6. Karel Pacak MD, PhD
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  7. Graeme Eisenhofer PhD
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Corresponding author

Correspondence to David S. Goldstein MD, PhD.

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Goldstein, D.S., Sharabi, Y., Karp, B.I. et al. Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Clin Auton Res 17, 118–121 (2007). https://doi.org/10.1007/s10286-007-0396-1

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  • DOI: https://doi.org/10.1007/s10286-007-0396-1

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