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Role of p38 and JNK in liver ischemia and reperfusion

  • Review article
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Background/purpose

The signal transduction of mitogen-activated protein kinases (MAPKs) has appeared to be an important mediator of ischemic-related events. Because of this, we analyzed the participation of p38 and JNK in liver ischemia and reperfusion, as two individual members of the MAPK family of proteins.

Methods

All papers referred to in PubMed for the past 15 years were analyzed to determine how and when these MAPKs were considered to be an intricate part of the ischemic event. References were cross-studied to ascertain whether other papers could be found in the literature.

Results

The role of p38 and JNK in liver ischemia was confirmed in the literature. The activation of these mediators was associated with the induction of apoptosis and necrosis. Inhibitors of p38 and JNK reduced the liver ischemia and reperfusion damage, probably through the mechanisms mentioned before.

Conclusions

The development of effective inhibitors of p38 and JNK protein mediators is important for minimizing the harmful effects associated with liver ischemia and reperfusion.

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Authors and Affiliations

  1. Departments of Research and Surgery, Kalamazoo Center for Medical Studies, Michigan State University, 1000 Oakland Drive, Kalamazoo, MI, 49008, USA

    LaShonda A. King & Luis H. Toledo-Pereyra

  2. Division of Abdominal Transplantation, University of North Carolina, Chapel Hill, NC, USA

    Alexander H. Toledo

  3. University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fernando A. Rivera-Chavez

Authors
  1. LaShonda A. King
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  2. Alexander H. Toledo
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  3. Fernando A. Rivera-Chavez
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  4. Luis H. Toledo-Pereyra
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Corresponding author

Correspondence to Luis H. Toledo-Pereyra.

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King, L.A., Toledo, A.H., Rivera-Chavez, F.A. et al. Role of p38 and JNK in liver ischemia and reperfusion. J Hepatobiliary Pancreat Surg 16, 763–770 (2009). https://doi.org/10.1007/s00534-009-0155-x

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  • DOI: https://doi.org/10.1007/s00534-009-0155-x

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