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Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

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Abstract

Purpose

To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season.

Methods

Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level.

Results

Eotaxin-1 concentration in tears of SAC patients [2,100±503 (SEM) pg/ml] and normal subjects (1,193±176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024).

Conclusions

The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

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Acknowledgments

We thank Marilita Moschos, MD, and Catherine Guex-Crosier for their assistance, the “Fonds Suisse de la Lutte contre la Cécité” (Pr Anne-Catherine Martenet), and the “Fondation pour la Recherche en Ophtalmologie de l’Hôpital Jules Gonin” for their financial support.

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Authors and Affiliations

  1. Ocular Immunology, Jules Gonin Eye Hospital, Av. De France 15, 1000, Lausanne 7, Switzerland

    Simone Eperon & Yan Guex-Crosier

  2. Pneumology, University Hospital (CHUV), Lausanne, Switzerland

    Alain Sauty

  3. Novartis Pharma, Business Unit Ophthalmics, Basel, Switzerland

    René Lanz

  4. Immunology and Allergy Unit, University Hospital (CHUV), Lausanne, Switzerland

    Annette Leimgruber & Floriana Lurati

Authors
  1. Simone Eperon
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  2. Alain Sauty
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  3. René Lanz
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  4. Annette Leimgruber
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  5. Floriana Lurati
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  6. Yan Guex-Crosier
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Corresponding author

Correspondence to Yan Guex-Crosier.

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Eperon, S., Sauty, A., Lanz, R. et al. Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis. Graefe's Arch Clin Exp Ophthalmol 242, 966–970 (2004). https://doi.org/10.1007/s00417-004-0943-6

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  • DOI: https://doi.org/10.1007/s00417-004-0943-6

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